Edward J. Dix, Ph.D

Professor of Chemistry

508-767-7292 Testa Science Center - Room 211

Degrees Earned

A.S., Corning Community College; Math and Science, 1986
B.S., Clarkson University; Chemistry, 1988
M.S., University of Rochester; Chemistry, 1990
Ph.D., University of Rochester; Chemistry, 1994
Ph.D. Thesis Title: “Studies on Reactive Intermediates: 1) 1,2-Hydrogen Shift in Alkylchlorocarbenes 2) Cyclobutane Ion Radical Cleavage”

Undergraduate Courses Taught

Organic Chemistry
Medicinal Chemistry

Publications & Editorships

Prodrugs of herpes simplex thymidine kinase inhibitors. M. Yanachkova, W. Xu, Sofya Dvoskin, E.J. Dix, I.B. Yanachkov, F. Focher, L. Savi, M.D. Sanchez, T.P. Foster, G.E. Wright. Antiviral Chemistry and Chemotherapy, doi: 10.1177/2040206615608722, October, 2015

New Highly Active Antiplatelets With Dual Specificity for P2Y1 and P2Y12 Platelet Receptors. I.B. Yanachkov, A.L. Frelinger III, H. Chang, M.I. Yanachkova, E.J. Dix, M.A. Berny-Lang, S.Wright, M.R. Barnard, A.D. Michelson, and G.E. Wright. European Journal of Medicinal Chemistry 107: 204-218 (2015)

Antiplatelet Activity, P2Y1 and P2Y12 Inhibition, and Metabolism in Plasma of Stereoisomers of Diadenosine 5′,5”’-P1,P4-dithio-P2,P3-chloromethylenetetraphosphate. H. Chang, E.J. Dix, Y.F. Li, M.R. Barnard, G.E. Wright, A.D. Michelson, A.L. Frelinger III and I.B. Yanachkov. PLoS ONE 9(4): e94780. doi:10.1371/journal.pone.0094780. Published April 10, 2014

Modified Diadenosine Tetraphosphates with Dual Specificity for P2Y1 and P2Y12 are Potent Antagonists of ADP-induced Platelet Activation. Chang, H; Yanachkov, I; Dix, E; Li, YF; Barnard, M; Wright, G; Michelson, A; Frelinger, A. Journal of Thrombosis and Haemostasis, 10: 1-8 (2013)

P1,P2-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates – Synthesis, Properties, and Use in Preparation of Dinucleoside Tetraphosphates and Analogs. Yanachkov IB, Dix EJ, Yanachkova MI, Wright GE, Org Biomol Chem. 2011; (9) 730

Hybrid Antibacterials. DNA Polymerase- Topomerase Inhibitors. C. Shi, Z. Long, A. Manikowski, J. Comstock, W.C. Xu, N.C. Brown, P. Tarantino, K. Holm, E. Dix, G. Wright, M. Barnes, M. Butler, K. Foster, W. LaMarr, B. Bachand, R. Bethell, C. Cadilhac, S. Charron, S. Lamothe, I. Motorina, R. Storer, J. Med. Chem., 2006, 49, 1455.

Synthesis and Antibacterial Activity of 3-Substituted-6-(3-ethyl-4-methylanilino)uracils. Zhi, C.; Long, Z.-y.; Manikowski, A.; Brown, N. C.; Tarantino, P. M., Jr.; Holm, K.; Dix, E. J.; Wright, G. E.; Foster, K. A.; Butler, M. M.; LaMarr, W. A.; Skow, D. J.; Motorina, I.; Lamothe, S.; Storer, R. J. Med. Chem.; 2005; 48(22); 7063

Protonation of Diarylcarbenes by Alcohols: The Importance of Ion Pair Dynamics. Edward J. Dix and Joshua L. Goodman, J. Phys. Chem., 1994, 98, 12609.

The Contribution of Quantum Mechanical Tunneling to the 1,2- Hydrogen Rearrangement of Methylbromocarbene. E.J. Dix and J.L. Goodman, Res. React. Intermed., 1993, 149

The 1,2-Hydrogen Rearrangement of Methylchlorocarbene: Contribution of Quantum Mechanical Tunneling. Edward J. Dix, Michael S. Herman, and Joshua L. Goodman, J. Am. Chem. Soc., 1993, 115, 10424.


“Pharmaceutical Development” Outreach presentation to the Wachusett High School Science Seminar students and advisors. Holden, MA, 28 October, 2014

Antiplatelet activity, P2Y1 and P2Y12 inhibition, and metabolism in plasma of diastereomers of the Ap4A analog diadenosine-5’,5”-P1,P4-dtion-P2,P3-chloromethylenetetraphosphate” Andrew L. Frelinger III, Hung Chang, Edward J. Dix, Milka Yanachkova, YouFu Li, Marc R. Barnard, George E. Wright, Alan D. Michelson, Ivan B. Yanachkov, XXIV Congress of the International Society on Thrombosis and Haemostasis, Amsterdam, the Netherlands, 1 July 2013.

Diadenosine tetraphosphate inhibitors of platelet aggregation: structure-activity relationships, P2Y1, P2Y12, and P2X1receptor selectivity, and in vivo antithrombotic effect. M.A. Berny-Lang, H. Chang, K. Przyklenk,M. Yanachkova, M.R. Barnard, J.K. Brooks, S. Zayas, A. Nigam, M. Lampa, E.J. Dix, G.E. Wright, A.D. Michelson, I.B. Yanachkov and A.L. Frelinger III. Platelets 2012 International Symposium, Beverly, MA, June, 2012.

Synthesis and Plasma Stability of Modified Diadenosine Tetraphosphates Edward Dix, et al. New England Regional Meeting of the American Chemical Society, Hartford, CT, October, 2009

Metabolism of Substituted Benzylguanine Gram + DNA Polymerase III Inhibitors, Poster, New England Drug Metabolism Discussion Group Summer Symposium, Shrewsbury, MA, June, 2005

Photochemistry of 6,6-dimethylbicyclo[3.3.1]: Intramolecular Hydrogen Atom Abstraction. Oral Presentation in the Organic Division, American Chemical Society National Meeting, San Diego, CA April1-4, 2001.

Invited speaker, Northeast Regional Meeting of the ACS. University of New Hampshire, June, 2001

Photochemistry of Bicyclic Ketones- presented at the Northeast Regional Meeting of the American Chemical Society, Clarkson University, Potsdam NY, June, 1999.