Aisling Dugan, Ph.D.

Associate Professor of Biology

508-767-7293 Testa Science Center - Room 204

Degrees Earned

B.A., Smith College, Biological Science, 2000
Ph.D., Brown University, Biology and Medicine, 2007
Postdoctoral Fellowship, Tufts University, 2009

Undergraduate Courses Taught

Microbiology & Laboratory
Immunology & Laboratory
Human Biology & Laboratory
Concepts in Biology Laboratory
Molecular and Cellular Biology Laboratory

Publications & Editorships

Love-Morris J, Gee GV, O’Hara BA, Assetta B, Atkinson AL, Dugan AS, Haley SA, Atwood WJ. JC polyomavirus uses extracellular vesicles to infect target cells. mBio. 2019. 10 (2): e00379-19.

Stroh LJ, Gee GV, Blaum BS, Dugan AS, Feltkampp MCW, Atwood WJ. Trichodysplasia Spinulosa-associated Polyomavirus employs a displayed binding site on VP1 to engage sialylated glycolipids. Plos Pathogen. 2015. 11 (8): e1005112. 

Asrat S, Dugan AS, Isberg RR. The frustrated host response to Legionella pneumophila is bypassed by MyD88-dependent translation of pro-inflammatory cytokines. Plos Pathogen. 2014. 10 (7): e1004229. 

Bouley SJ, Maginnis MS, Derdowski A, Gee GV, O’Hara BA, Nelson CD, Bara AM, Atwood WJ, Dugan AS. Host cell autophagy promotes BK virus infection. Virology. 2014. 456-457: 87-95. 

Barry KC, Fontana MF, Portman JL, Dugan AS, Vance RE. IL-1α Signaling Initiates the Inflammatory Response to Virulent Legionella pneumophila In Vivo. Journal of Immunology. 2013. 190(12):6329-39. 

Jordan JA, Manley K, Dugan AS, O’Hara BA, Atwood WJ. Transcriptional regulation of BK virus by nuclear factor of activated T cells. Journal of Virology. 2010. 84 (4): 1722-30. 

Li Z, Dugan AS, Bloomfield G, Skelton J, Ivens A, Losick V, Isberg RR. DupA: a key regulator of the amoebal MAP kinase response to Legionella pneumophila. Cell Host & Microbe. 2009. 6 (3): 253-267. 

Gasparovic ML, Maginnis MS, O'Hara BA, Dugan AS, Atwood WJ. Modulation of PML protein expression regulates JCV infection. Virology. 2009. 390 (2): 279-288. 

Dugan AS, Maginnis MS, Jordan JA, Gasparovic ML, Manley K, Page R, Williams G, Porter E, O’Hara BA, Atwood WJ. Human alpha-defensins inhibit BK Virus by aggregating virions and blocking binding to host cells. Journal of Biological Chemistry. 2008. 283 (45): 31125-31132.

Presentations

Knoll, S., Allain, N., and Dugan AS. The Microbial Community of Kitchen Sponges: Experimental Study Investigating Bacterial Number, Composition, and Resistance. (2019) Pioneer Valley Microbe Symposium, Amherst, MA

 

Dugan, AS. Out of the Classroom and into the Community: Integrating a Service Learning Project to an Immunology course (2018) Project Kaleidoscope (PKAL) Regional Summer Meeting, Salem State University, Salem, MA

 

Dugan, AS. A Virus in Cell Clothing. (2017) Rhode Island College, Biology Dept. Colloquium Seminar Series, Providence, RI

 

Dugan, AS. Extracellular Vesicle Involvement in JC Polyomavirus Infection. (2017) ASM (American Society for Microbiology) Microbe Conference, New Orleans, LA

 

Dugan, AS. Exosome Involvement in JC Polyomavirus Infection. (2017)6th International Society for Extracellular Vesicles Conference, Toronto, Canada

 

Dugan, AS. Exosome Involvement in JC Polyomavirus Infection. (2017) 2nd Northeast Association for Clinical Microbiology and Infectious Disease & Northeast Branch of American Society for Microbiology (NACMID-NEB-ASM) Conference, Wakefield, MA

 

Dugan, AS. Host Cell Autophagy Promotes BK virus Infection. (2014) American Society for Microbiology 114th General Meeting, Boston, MA

 

Dugan, AS. The Ins and Outs of BK Virus Infection. (2014) Bryant University, Dept. of Science and Technology Seminar Series, Smithfield, RI

 

Research Projects

Assumption Student Research Projects 

Sydney Knoll ‘19

Project: Exploring the microbial environment of a kitchen sponge

Current Position: Doctor of Nursing Practice Program at UMASS Medical School
 

Nicholina Allain ’19 

Project: You are what you eat: Investigating stable isotopes in human hair
 

Lauren Pepi ’15 

Project: Cell Cycle Inhibition Influences BK Virus Infection
Current position: Graduate student in Ph.D. program in Chemistry at the University of Georgia (Fall 2015-present)

Sarah William ’14

Project: The Effect of Elafin on BK Virus Infection
Current position: Graduate student in Masters of Public Health Program at Boston University (Fall 2015- present)

Maggie Bara ‘14, 

Project: Immune Response to Dermacoccus Infection
Current Position: Research Associate I at Broad Institute of Harvard and MIT (July 2014-present)

Matt Cooke ’13, Assumption College

Project: Testing for Enterovirus in Blackstone Valley Wastewater Treatment Center
Current position: Associate Scientist I at Leica Biosystems, Danvers, MA (2014-present)

Stephanie Bouley ’12, Assumption College

Project: Understanding the Role of Autophagy in BK Virus Infection
Received Fulbright Scholarship, University of Tubingen, Germany (2012-2013)
Current position: Ph.D. Graduate student in Program in Experimental and Molecular Medicine at Dartmouth College, Hanover, NH (2013-present)