David Crowley, Ph.D.

Director of ASPIRE

Associate Director of the Center for Purpose and Vocation

Degrees Earned

B.A., College of the Holy Cross, Cum Laude with Honors in Biology, 1993
Ph.D., Stanford University, in Biological Sciences, 1999
M.A., Anna Maria College, in Pastoral Ministry, 2013

Undergraduate Courses Taught

Concepts in Biology
Genetics
Cellular and Molecular Biology

Publications & Editorships

Nag, S., DasSarma, P., Crowley, D.J., *Hamawi R., *Tepper, S., Anton, B., Guzmán, D., and DasSarma, S. 2023. Genomic analysis of Haloarchaea from diverse environments, including Permian halite, reveals diversity of ultraviolet radiation survival and photolyase gene variants. Microorganisms, 11(3):607.

Volkert, M.R. and Crowley, D.J.  2020. Preventing Neurodegeneration by Controlling Oxidative Stress: The Role of OXR1. Frontiers in Neuroscience, 14:1318.

*Stantial, N., *Dumpe, J., *Pietrosimone, K., *Baltazar, F. and Crowley, D.J. 2016. Transcription-coupled repair of UV damage in the halophilic archaea. DNA Repair, 41:63-68.

Boubriak, I., Ng, W.L., DasSarma, P., DasSarma, S. Crowley, D.J., and McCready, S. 2008. Transcriptional responses to biologically relevant doses of UV-B radiation in the model archaeon, Halobacterium sp. NRC-1.  Saline Systems. 4(1):13.

Crowley, D.J., Boubriak, I., Berquist, B.R., *Clark, M., *Richard, E., *Sullivan, L., DasSarma, S. and McCready, S.  2006.  The uvrA, uvrB, and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1.  Saline Systems, 2(1):11.

Crowley, D.J. and Courcelle, J.C.  2002. Answering the call:  Coping with DNA damage at the most inopportune time.  Journal of Biomedicine and Biotechnology 2(2):66-74.

Hoffmann, G.R., Crowley, D.J. and Theophiles, P.J.  2002.  Comparative potencies of induction of point mutations and genetic duplications by the methylating agents methylazoxymethanol and dimethyl sulfate in bacteria.  Mutagenesis 17(5):439-444.

Crowley, D.J. and Hanawalt, P.C.  2001.  The SOS-dependent upregulation of uvrD is not required for efficient nucleotide excision repair of ultraviolet light induced DNA photoproducts in Escherichia coli. Mutation Research 485(4):319-329.

Hanawalt P.C., Crowley D.J., Ford J.M., Ganesan A.K., Lloyd D.R., Nouspikel T., Smith C.A., Spivak G., Tornaletti S.  2000.  Regulation of nucleotide excision repair in bacteria and mammalian cells.  In: Cold Spring Harbor symposia on quantitative biology, Vol. 65:  Biological Responses to DNA Damage. p. 183-191.

Courcelle, J., Crowley, D. J., Hanawalt, P.C.  1999.  Recovery of DNA replication in UV-irradiated Escherichia coli requires both excision repair and RecF protein function.  Journal of Bacteriology, 181(3):916-922.

Crowley, D.J. and Hanawalt, P.C.  1998.  Induction of the SOS response increases the efficiency of global nucleotide excision repair of cyclobutane pyrimidine dimers, but not 6-4 photoproducts, in UV-irradiated Escherichia coli.  Journal of Bacteriology, 180(13):3345-3352.

Zou, Y., Crowley, D.J., and Van Houten, B.  1998.  Involvement of molecular chaperonins in nucleotide excision repair.  Journal of Biological Chemistry, 273(21):12887-12892.

Sweder, K.S., Verhage, R.A., Crowley, D.J., Crouse, G.F., Brouwer, J. and Hanawalt, P.C.  1996.  Mismatch repair mutants in yeast are not defective in transcription-coupled repair of UV-induced DNA damage.  Genetics, 143:1127-1135.

Volkert, M.R., Loewen, P.C., Switala, J., *Crowley, D., Conley, M.  1994.  The delta (argF-lacZ) 205(U169) deletion greatly enhances resistance to hydrogen peroxide in stationary-phase Escherichia coli.  Journal of Bacteriology, 176(5):1297-1302.

* Indicates undergraduate co-author